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. 2020 Jan 29;45(6):982–989. doi: 10.1038/s41386-020-0624-0

Fig. 3. Comparison of the three preprocessing strategies on measures of global brain connectivity (GBC) in 22 healthy controls (HCs) at baseline.

Fig. 3

a Unthresholded GBC maps (group average) with white matter (WM)/cerebrospinal fluid (CSF) regression (BASE) resembled those with WM/CSF regression + physiological parameter regression (PHYSIO). GBC maps after WM/CSF + global signal regression (GSR) yielded peaks around the basal ganglia, insulae, and cingulate cortices. Negative Fisher-transformed Z-scores (Fz-scores) were introduced in terminal fields along the anterior–posterior axis. b Absolute Fz-score distributions corresponding to a. Fz-scores centered around zero after GSR; color-coding represents tail probabilities around the median (dark line). c Comparison between BASE regression and GSR GBC maps yielded strong brain-wide reductions in Fz-scores with an emphasis on posterior-basal regions. Histograms depict total gray matter (GM) Fz-scores in 22 HCs at baseline; lines represent means.