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. 2020 Feb 24;45(6):990–997. doi: 10.1038/s41386-020-0644-9

Fig. 1. The study drug effect on Montgomery Åsberg Depression Rating Scale (MADRS).

Fig. 1

a There is a significant main effect of time (F(8,245) = 43.5, p < 0.0001), demonstrating significant decrease in MADRS scores from baseline. There is also significant interaction between treatment and time (F(8,245) = 2.0, p = 0.04), with overall reduction in depression scores following treatment with rapamycin + ketamine (rapamycin; blue line), compared to post placebo + ketamine (placebo; red line). Primary outcome time points included: before infusion, and 1, 2, 4, 24 h, 3 days, 5 days, 1 week, and 2 weeks after infusion. Dashed lines refer to assessments at 1, 2, and 4 h. b Response and remission rates following treatment with rapamycin + ketamine (rapamycin; blue), compared to post placebo + ketamine (placebo; red). Notes: Error bars are standard errors of mean (SEM); d′ = Cohen’s d′ effect size compared to pretreatment MADRS scores.