Table 1.
Demographics and clinical characteristics.
| Patients (n = 20) | |
|---|---|
| Age (mean ± SEM) | 42.8 ± 2.8 years |
| Women | 12 |
| Race (white) | 15 |
| Education (mean ± SEM) | 8.4 ± 0.3 years |
| BMI (mean ± SEM) | 27.2 ± 1.3 kg/m2 |
| CRP (mean ± SEM) | 2.4 ± 0.8 mg/L |
| ESR (mean ± SEM) | 11.5 ± 2.3 mm/h |
| T-0 h Rapamycin (mean ± SEM) | 26.5 (±2.4) ng/mL |
| T-4 h Rapamycin (mean ± SEM) | 9.9 (±1.0) ng/mL |
| Concomitant medications | None (N = 1) |
| SRI (N = 14) | |
| Mood stabilizer or SGA (N = 3) | |
| Other antidepressants (N = 5) | |
| Stimulants (N = 2) | |
| Sedatives (N = 7) | |
| Other psychotropics (N = 3) | |
| Non-psychotropics (N = 10)a | |
| Psychiatric hospitalization history | 8 |
| Family psychiatric history | 12 |
| Treatment failures (mean ± SEM) | 5.1 (±0.9) |
SEM standard error of means, BMI body mass index, CRP C reactive protein, ESR erythrocyte sedimentation rate, T-0 h immediately prior to ketamine infusion, T-4 h four hours post infusion, SRI serotonin reuptake inhibitor, SGA second generation antipsychotics.
aNon-psychotropics were primarily for diabetes, hypertension, GERD, or hypothyroidism.