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. 2020 Apr 16;10:6570. doi: 10.1038/s41598-020-63463-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Map of nine cagPAI proteins with known functional domains (in green) and the position of 19 amino acid changes derived by non-synonymous SNPs with a statistically significant distribution (P < 0.05) between gastritis and gastric cancer cases (light green); gastritis and intestinal metaplasia gastric cancer cases pooled together (dark blue) and gastritis and intestinal metaplasia cases (light blue).