Table 3.

Polymorphisms in cagPAI genes showing a differential distribution between gastritis and IM or GC cases.

Gene	Nucleotide change	Amino acid change	Frequency in controls	Frequency in IM	OR (CI)	Frequency in cancer	OR (CI)	P-value for trend
cagA	G154A	V52I	0	0.17	15.13 (0.84–311.2)a	0.17	16.0 (0.71–359.3)	0.029
cagA	G193A	G65R	0.03	0.17	6.40 (0.61–66.76)	0.25	10.67 (0.99–115.36)	0.026
cagA	C581T	S194F	0	0.22	20.79 (1.05–411.83)a	0.08	8.74 (0.33–229.93)	0.110
cagA	A1280G	Q/K427R	0.7	1	16.53(0.91–300.97)a	0.92	4.78 (0.54–42.21)	0.024
cagA	C1279A	Q/R427K	0.21	0	0.10 (0.01–1.78)a	0	0.14 (0.01–2.68)	0.017
cagA	AA1399–1400GG	N467G	0.42	0.67	2.71 (0.82–9.00)	0.83	6.79 (1.28–35.97)a	0.010
cagA	GTT/CCC3121–3123ACC	V/P1041T	0.3	0.67	4.60 (1.35–15.73)a	0.42	1.64 (0.42–6.44)	0.190
cagC	G64A	V22I	0.14	0.19	1.51 (0.35–6.36)	0.63	10.67 (2.68–42.53)a	0.001
cagC	G109A	V37I	0.11	0.33	4.13 (1.04–16.37)	0.38	4.95 (1.16–21.09)	0.019
cagC	A133G	I45V	0.08	0.19	2.67 (0.54–13.29)	0.44	8.81 (1.89–41.08)a	0.003
cagE	A2941G	K981E	0.32	0.05	0.10 (0.01–0.87)a	0.13	0.30 (0.06–1.52)	0.039
cagL	C29T	S10F	0.78	0.33	0.14 (0.04–0.46)a	0.75	0.83 (0.21–3.28)	0.310
cagX	GG31–32AA	G11N	0.54	0.19	0.20 (0.06–0.71)a	0.31	0.39 (0.11–1.33)	0.040
HP0520_cagζ	T103G	S35A	0.11	0.52	8.80 (2.29–33.84)a	0.0625	0.53 (0.05–5.19)	0.626
HP0522_cagδ	G1057A	V353I	0.56	0.81	3.40 (0.95–12.13)	0.75	2.40 (0.65–8.88)	0.093
HP0522_cagδ	C1217T	P406L	0.14	0.24	1.94 (0.49–7.69)	0.5625	7.97 (2.03–31.27)a	0.0023
HP0522_cagδ	AAT1219–1222GAG	N407E	0.11	0.24	2.50 (0.59–10.61)	0.5625	10.29 (2.45–43.15)a	0.0008
HP0524_cagβ	AAT373–375GCA	N125A	0.92	0.76	0.29 (0.06–1.37)	0.6	0.14 (0.03–0.66)a	0.008
HP0534_cagS	GC437–438AT	G146D	0.60	0.81	2.83 (0.79–10.21)	0.875	4.67 (0.92–23.79)	0.028

^aP < 0.05 by Fisher Exact test.