Table 2.

Elastic-net regression coefficients for multinomial and binomial elastic regressions.

Region	Multinomial BD vs. HC vs. MDD			Binomial BD vs. MDD Neuroimaging+Clinical	Binomial BD vs. MDD Neuroimaging only	Binomial BD vs. MDD Clinical only
	BD	MDD	HC
∆cue left DLPFC fearful faces	−1.331	1.607	−0.276	1.85	2.4	NA
∆task left DLPFC fearful faces	–	–	–	–	−0.92	NA
∆cue * ∆task left DLPFC fearful faces	4.463	−5.345	0.883	−0.55	−4.88	NA
∆task left DLPFC neutral faces	–	–	–	–	−0.93	NA
∆cue left VLPFC neutral faces	1.115	−1.463	0.348	−0.85	−1.25	NA
∆cue Paracingulate/dACC neutral faces	0.437	−0.404	−0.033	−0.70	−0.95	NA
∆cue * ∆task Paracingulate/dACC neutral faces	−2.073	2.422	−0.348	2.94	7.98	NA
Current depression severity (HRSD-25)	0.019	0.01	−0.028	−0.01	NA	−0.02
Current mania severity (YMRS)	0.014	−0.007	−0.007	–	NA	–
Lifetime depression (MOODS-SR)	0.015	0.039	−0.054	–	NA	–
Lifetime mania (MOODS-SR)	0.062	−0.038	−0.024	−0.08	NA	−0.09
Lifetime mood mixed instability (MOODS-SR)	0.075	−0.035	−0.04	−0.07	NA	−0.06
Lifetime irritability (MOODS-SR)	0.095	−0.006	−0.089	−0.10	NA	−0.12
Anhedonia (SHAPS)	0.008	0.007	−0.015	–	NA	–
State anxiety (STAIY1)	0.004	0.014	−0.018	–	NA	–
Trait anxiety (STAIY2)	0.005	0.007	−0.012	–	NA	–
A total medication load	0.07	0.006	−0.076	–	NA	–

“NA”—the variable was not among the input variables to the model, “–“ —the variable was not selected by elastic net.