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. 2020 Apr 16;11(4):233. doi: 10.1038/s41419-020-2426-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — MKN45 cells were transfected with pcDNA3.1 or pcDNA3.1/HCP5. Mice were injected with MKN45 cells and received FOLFOX regime weekly (oxaliplatin 6 mg/kg followed 2 h later by 5-florouracil 50 mg/kg and calcium folinatc 90 mg/kg, intraperitoneally (i.p.). a Tumor volumes were calculated every 4 days, and the growth curve was drawn. b Tumor weight and volume of each group was assessed 28 days after injection. c The relative levels of HCP5, miR-3619-5p, PPARGC1A and CPT1 in xenografts of each group were detected by RT-qPCR. d IHC staining of PGC1α, CPT1, and proliferation index Ki67 in xenografts of each group. e HE staining of the metastatic nodes in lungs of mice of each group. **P < 0.01. Error bars indicate SD. Each assay was conducted for three times.