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. 2020 Apr 16;10:6538. doi: 10.1038/s41598-020-63398-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depiction of cell treatment models. iPSC-derived neurons are first differentiated for 60 days, then treated with 1 µM oligomeric amyloid-beta for 24 h. Neurons are collected and used for Western blot, or with nLC-MS/MS (whole proteome analysis and phosphoenrichment). Quantification is performed by densitometry (Western blot) and by label-free quantification (LFQ) using Scaffold proteomics software. Fold-change values were compared between both methods to validate the LFQ method.