Table 5.
Significantly up- and downregulated proteins in the proteome of ADP2 cells resulting from 24 h oAβ treatment.
| Identified Proteins | Protein ID | AF22 T-Test (p-value) | AF22 Fold Change | ADP2 T-Test (p-value) | ADP2 Fold Change |
|---|---|---|---|---|---|
| Alpha-2-macroglobulin receptor-associated protein | AMRP_HUMAN | 0.33 | 2.1 | 0.021 | INF |
| Coatomer subunit gamma-1 | COPG1_HUMAN | 0.66 | 0.8 | 0.028 | 0.2 |
| Isoform 2 of Serine/threonine-protein kinase DCLK2 | DCLK2_HUMAN | 0.33 | 0.5 | 0.031 | 8 |
| Isoform Cytoplasmic of Fumarate hydratase, mitochondrial | FUMH_HUMAN | 0.14 | 1.5 | 0.012 | 2.6 |
| Cluster of Isoform 2 of Eukaryotic initiation factor 4A-II | IF4A2_HUMAN | 0.93 | 1 | 0.029 | 0.5 |
| Cluster of Isoform Delta 10 of Calcium/calmodulin-dependent protein kinase type II subunit delta | KCC2D_HUMAN | 0.68 | 1.2 | 0.011 | 2.5 |
| Isoform 2 of Nucleosome assembly protein 1-like 1 | NP1L1_HUMAN | 0.55 | 0.9 | 0.041 | 2 |
| Proteasome subunit alpha type-4 | PSA4_HUMAN | 0.98 | 1 | 0.0084 | 4.3 |
| 60 S acidic ribosomal protein P1 | RLA1_HUMAN | 0.85 | 0.9 | 0.032 | 2 |
| Isoform 2 of Neuronal-specific septin-3 | SEPT3_HUMAN | 0.29 | 1.4 | 0.037 | 3.8 |
| Serine/arginine-rich splicing factor 2 | SRSF2_HUMAN | 0.76 | 0.9 | 0.043 | 2.3 |
The provided table depicts proteins with significant changes in expression (p < 0.05, T-test with Benjamini-Hochberg correction) in cells challenged with oAβ relative to untreated cells (i.e. ADP2 + oAβ relative to ADP2 control). ADP2: n = 7 (control), n = 7 (oAβ treated). Data represent analysis of whole proteome preparations. AF22 columns provided for comparison. AF22: n = 16 (control), n = 14 (oAβ treated). ND = Not detected.