Table 2.

Protein expression and phosphorylation status of key proteins in the AKT-mTOR signaling pathway in SZ and comparison subjects.

Protein	Comparison	Schizophrenia	Test statistic	p value
AKT	1.23 ± 0.10	1.01 ± 0.06	t (21) = 2.21	0.04*
Phospho-AKT S473/AKT	0.76 ± 0.08	0.60 ± 0.04	t (20) = 2.04	0.05*
Phospho-AKT T308/AKT	0.94 ± 0.10	0.80 ± 0.06	t (21) = 1.91	0.07
PDK1	2.13 ± 0.29	2.10 ± 0.24	t (21) = 0.14	0.89
Rheb	1.15 ± 0.15	1.27 ± 0.16	t (20) = 1.41	0.17
mTOR	2.82 ± 0.30	2.56 ± 0.39	t (21) = 1.10	0.28
Phospho-mTOR S2448/mTOR	1.14 ± 0.07	0.91 ± 0.07	t (21) = 2.94	0.01*
Phospho-mTOR S2481/mTOR	0.98 ± 0.11	1.04 ± 0.18	W = −25	0.68
GβL	1.18 ± 0.11	0.98 ± 0.07	t (20) = 2.38	0.03*
Deptor	0.07 ± 0.01	0.08 ± 0.02	W = 24	0.71
Raptor	1.74 ± 0.09	1.74 ± 0.15	t (21) = 0.05	0.96
Rictor	0.39 ± 0.07	0.35 ± 0.05	t (21) = 0.89	0.38

Signal intensities of each measure from immunoblotting represented as means ± SEM

*p ≤ 0.05