Figure 2.

Study of Antitumor Memory in Complete Responders

(A) Experimental design: animals treated with ACT and different oncolytic viruses (or PBS) experiencing complete responses were rechallenged with HapT1 and challenged with DDT1-MF2 to study antitumor-specific memory (no additional treatments given). In addition, naive animals were simultaneously engrafted with HapT1 and DDT1-MF2 tumors. (B) Groups included in the experiment: naive animals group (n = 3), PBS + TILs group (n = 1), adenovirus + TILs group (n = 5), vaccinia + TILs (n = 1), and reovirus + TILs (n = 1). The number of animals depended on how many had been cured in the first part of the experiment. (C) Mean (and SEM) tumor volumes for the HapT1 tumors. (D) Mean (and SEM) tumor volumes for the DDT1-MF2 tumors.