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Viral Dose Extrapolation According to Maximum-Tolerated Doses in Humans
| Virus | Reference | Year | Maximum Dose (Human) | Extrapolated Dose (Hamster) |
|---|---|---|---|---|
| Adenovirus | Small et al.71 | 2006 | 6 × 1012 vp | 8 × 109 vp |
| Vaccinia | Zeh et al.72 | 2015 | 3 × 109 PFU | 4 × 106 PFU |
| Herpes simplex | Andtbacka et al.47 | 2015 | 4 × 108 PFU | 5.3 × 105 PFU |
| Reovirus | Karapanagiotou et al.73 | 2012 | 3 × 1010 TCID50 | 4 × 107 TCID50 |
vp, viral particle; PFU, plaque-forming unit; TCID50, median tissue-culture infectious dose.
