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. 2020 Mar 30;17:83–93. doi: 10.1016/j.omto.2020.03.009

Figure 6.

Figure 6

miR-140-3p Activates JNK Signaling and Inhibits the AKT/p70S6K Pathway in CM Cells

(A) Expression levels of AKT, p-AKT, p70S6k, p-p70S6k, JNK, p-JNK, and apoptotic and EMT-related proteins in A375 cells with different treatments (as indicated) determined by western blot analysis. (B) Relative expression of AKT, p-AKT, p70S6k, p-p70S6k, JNK, p-JNK, cleaved-caspased3, vimentin, and E-cadherin in A375 cells with different treatments. (C) Expression of vimentin and E-cadherin in A375 cells determined by immunofluorescence assay (×400). *p < 0.05 vs. miR-NC; #p < 0.05 vs. miR-140-3p+ctrl.