Figure 6.

OBP-702 Inhibits Tumor Growth in an Orthotopic BxPC-3-Luc Xenograft Tumor Model

BxPC-3-Luc cells (3 × 10⁶ cells/site) were inoculated into the pancreatic tails of athymic nude mice. OBP-301 (10⁸ PFUs/tumor), OBP-702 (10⁸ PFUs/tumor), or PBS (mock) was injected into the tumors on days 0, 2, and 4. Luminescence in tumor tissues was analyzed using an IVIS system at 0, 7, 14, 21, and 28 days after first treatment. (A) Representative photographs of mock-, OBP-301-, or OBP-702-treated tumor-bearing mice. (B) Data are expressed as mean ± SD (mock group: n = 12; OBP-301 and OBP-702 groups: n = 10). ∗p < 0.05.