Table 2.
Univariate and multivariate Cox regression analyses in HNSCC patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age at initial diagnosis (≥60 vs < 60) | 1.385 (1.027‐1.869) | .033 | 1.372 (1.017‐1.851) | .038 |
| Gender (Female vs Male) | 1.317 (0.967‐1.794) | .081 | ||
| T stage (T3 + T4 vs T1 + T2) | 1.430 (1.037‐1.972) | .029 | 1.386 (1.004‐1.912) | .047 |
| N stage (N1‐3 vs N0) | 1.097 (0.823‐1.462) | .528 | ||
| M stage (M1 vs M0) | 2.374 (0.757‐7.448) | .138 | ||
| Clinical stage (III + IV vs I + II) | 1.234 (0.864‐1.761) | .247 | ||
| Histologic grade (G3 + G4 vs G1 + G2) | 0.850 (0.613‐1.179) | .33 | ||
| SDEM‐signature (High risk vs Low risk) | 1.464 (1.094‐1.959) | .01 | 1.431 (1.068‐1.917) | .016 |