Table 2.
Univariate and multivariate analysis of OS and RFS in the training cohort
| Variables | OS | RFS | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Univariate analysis | ||||||
| Age, y | 0.995 | 0.977‐1.014 | .608 | 0.995 | 0.981‐1.009 | .483 |
| Sex (Male, Female) | 1.635 | 0.759‐3.522 | .209 | 1.841 | 1.024‐3.310 | .042 |
| HBsAg (Negative/Positive) | 0.871 | 0.487‐1.558 | .641 | 1.177 | 0.722‐1.919 | .513 |
| TB, μmol/L | 1.014 | 1.003‐1.024 | .010 | 1.009 | 0.999‐1.020 | .090 |
| ALB, g/L | 0.939 | 0.907‐0.972 | <.001 | 0.952 | 0.925‐0.980 | .001 |
| ALT, IU/L | 1.002 | 1.000‐1.005 | .081 | 1.001 | 0.999‐1.004 | .417 |
| AST, IU/L | 1.001 | 0.998‐1.003 | .602 | 1.000 | 0.997‐1.002 | .680 |
| GGT, IU/L | 1.001 | 1.001‐1.002 | .001 | 1.001 | 1.000‐1.002 | .026 |
| LDH, IU/L | 1.001 | 0.999‐1.003 | .339 | 1.000 | 0.998‐1.002 | .697 |
| ALP, U/L | 1.008 | 1.005‐1.010 | <.001 | 1.005 | 1.002‐1.007 | <.001 |
| CEA, μg/L | 1.007 | 0.903‐1.122 | .904 | 1.010 | 0.929‐1.098 | .815 |
| CA19‐9, μg/L | 1.005 | 1.001‐1.008 | .008 | 1.002 | 0.999‐1.006 | .227 |
| Tumor size, cm | 1.145 | 1.091‐1.203 | <.001 | 1.099 | 1.053‐1.147 | <.001 |
| Blood loss, mL (<400/≥400) | 1.796 | 1.179‐2.734 | .006 | 1.460 | 1.037‐2.055 | .030 |
| HBV‐DNA load, IU/mL (<2000/≥2000) | 1.498 | 1.019‐2.201 | .040 | 1.172 | 0.869‐1.581 | .299 |
| Tumor number (Single/Multiple) | 1.567 | 0.858‐2.861 | .143 | 2.466 | 1.600‐3.799 | <.001 |
| Major resection (No/Yes) | 1.943 | 1.285‐2.938 | .002 | 1.531 | 1.093‐2.144 | .013 |
| MVI (No/Yes) | 2.241 | 1.486‐3.378 | <.001 | 1.860 | 1.333‐2.594 | <.001 |
| Satellite lesions (No/Yes) | 2.685 | 1.775‐4.061 | <.001 | 1.879 | 1.327‐2.660 | <.001 |
| Liver cirrhosis (No/Yes) | 1.516 | 1.026‐2.240 | .037 | 1.361 | 1.010‐1.835 | .043 |
| Edmondson‐Steiner grade (I + II/III + IV) | 2.312 | 1.405‐3.805 | .001 | 1.556 | 1.108‐2.184 | .011 |
| Child‐Pugh (A/B) | 2.055 | 0.756‐5.586 | .158 | 0.815 | 0.260‐2.553 | .726 |
| Multivariate analysis | ||||||
| ALP, U/L | 1.005 | 1.001‐1.009 | .025 | 1.004 | 1.001‐1.008 | .017 |
| Liver cirrhosis (No/Yes) | 1.888 | 1.224‐2.914 | .004 | 1.479 | 1.075‐2.036 | .016 |
| Tumor size, cm | 1.178 | 1.086‐1.278 | <.001 | 1.133 | 1.056‐1.216 | .001 |
| Satellite lesions (No/Yes) | 2.264 | 1.410‐3.637 | .001 | 1.522 | 1.033‐2.242 | .034 |
| MVI (No/Yes) | 1.688 | 1.057‐2.697 | .029 | 1.461 | 1.014‐2.105 | .042 |
| Edmondson‐Steiner grade (I + II/III + IV) | 2.368 | 1.415‐3.962 | .001 | 1.545 | 1.085‐2.202 | .016 |
| Sex (Male, Female) | 2.231 | 1.205‐4.132 | .011 | |||
| Tumor number (Single/Multiple) | 1.757 | 1.114‐2.773 | .015 | |||
Abbreviations: ALB, albumin; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; CA19‐9, carbohydrate antigen 19‐9; CEA, carcino‐embryonic antigen; GGT, γ‐glutamyl transferase; HBsAg, hepatitis B surface antigen; HBV‐DNA, hepatitis B virus deoxyribonucleic acid; LDH, lactate dehydrogenase; MVI, microvascular invasion; OS, overall survival; RFS, recurrence free survival; TB, total bilirubin.
P < .05 was defined as statistical significance.