FIG 12.

Serum/plasma markers of microbial translocation in SIV-infected and uninfected rhesus macaques. (A) Concentration of zonula occludens-1 (ZO-1) in the serum of the ten uninfected and ten SIV-infected animals used in the studies described in Fig. 4 and 6 were determined by ELISA. (B) Serum concentration of Dickkopf-related protein 1 (DKK1) was determined by ELISA. (C) Serum concentration of intestinal fatty-acid binding protein (iFABP) was determined by ELISA. (D) Concentration of lipopolysaccharide (LPS) in serum taken from the ten uninfected (gray bars) and ten SIV-infected (green bars) rhesus macaques used in the studies described in Fig. 4 and 6 was determined by Limulus amoebocyte lysate assay. Horizontal lines in boxes indicate the medians, boxes are the upper and lower quartiles, and vertical lines indicate variability outside the upper and lower quartiles. Individual points are outliers. The P values for statistical significance were determined using Mann-Whitney U test. The P value threshold for significance was P < 0.05.