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. 2020 Apr 16;94(9):e00071-20. doi: 10.1128/JVI.00071-20

FIG 3.

FIG 3

RdRP mice show resistance and signs of recovery during low-dose chronic FV infection. Mixed-gender mice 16 to 17 weeks of age were retro-orbitally injected with 2,500 PFU of B-tropic FV. At 4 weeks after infection, spleens were harvested to assess splenomegaly by weight (A) and photography (C), and plasma was harvested to determine plasma viral load by qPCR (B). (D) Correlation analysis of plasma viral load versus spleen weight. Plasma viral load was log transformed before analysis, and correlation analysis was done to determine significance. For all experiments, n = 5 for uninfected, n = 9 for WT, and n = 7 for RdRP. For spleen weights, data were analyzed using a one-way ANOVA followed by a Tukey test to determine significance. For plasma viral loads, data were log transformed and then analyzed using a Student's t test. For correlation analysis (D), plasma viral load was log transformed, and correlation analysis and a Pearson’s test was run. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.