FIG 4.

Correlates of protection in RdRP mice. (A) Total splenocytes from uninfected WT and RdRP mice stained for markers to identify T cells, B cells, DCs, natural killer (NK) cells, or erythroblasts. (B, C) MFI of BST-2 expression on total splenocytes (B) or on cellular subsets (C), stained as described in panel A. For WT, n = 10, and RdRP, n = 11. (D, E) RBC-lysed splenocytes were stained for DC subsets (D) and CD80/CD86 expression (E) to determine cellular activation status. In panels D and E, n = 5 for WT and 5 for RdRP. Data for all experiments were analyzed using an unpaired Student's t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.