FIG 7.
FNC inhibits the transcription of EVs through interacting with 3Dpol. (A to E) FNC inhibited both positive- and negative-strand RNA production of EV71 (A), CA16 (B), CA6 (C), CVB3 (D), and EVD68 (E). RD cells were infected with the indicated EVs, treated with the indicated concentration of FNC for 48 h, and harvested for RNA extraction and RT-qPCR. GAPDH was used to normalize the cells. The asterisks indicate statistically significant differences between groups, as assessed by Student's t test (*, P ≤ 0.05; **, P ≤ 0.01; and ***, P ≤ 0.001; ns, not significant).