FIG 1.

IRF5 alters cytokine responses to influenza A virus in a murine infection model. WT and Irf5^−/− mice were infected intranasally with 3 × 10³ A/X-31 influenza virus. (A) Inflammatory cytokine expression in BAL fluid was measured using multiplex assays 2, 4, and 7 days p.i. Data shown are the mean ± SEM using 7 WT and 5 Irf5^−/− mice (day 2) or five mice per genotype (day 4 and day 7) and represent the results from two independent experiments. (B) IFN-α and IFN-β levels in BAL fluid measured by ELISA in Irf5^−/− and WT naive and IAV-infected mice at 2 days p.i. Data shown are the mean ± SEM of the results from 3 to 6 mice per group at 2 days p.i.