FIG 4.

Surface properties of the CtenRNAV-II capsid. The major CPs are colored according to the following code: VP1, light green; VP2, light blue; VP3, dark blue. (A) Unique EF-loop of VP1 in CtenRNAV-II. The ninth strand (βE2), EF-loop, and the following helix of VP1 in CtenRNAV-II are highlighted in pale green. The EF-loop is exposed on the surface of the capsid around the five-fold axes. (B) Superimposition of VP1 from CtenRNAV-II (light green) with VP1 from representatives of the invertebrate, vertebrate, and plant virus families of the order Picornavirales: Cricket paralysis virus (CrPV) (1B35), Deformed wing virus (DWV) (5L8Q), hepatitis A virus (HAV) (4QPI), enterovirus 71 (EV71) (3VBF), and Cowpea mosaic virus (CPMV) (1NY7) in different shades of gray. (C) Structural comparison between poliovirus (PV) (1HXS) and CtenRNAV-II with a closer look at the surfaces of the biological protomers. For CtenRNAV-II, the C-terminal residues and the CD-loop of VP1, which obscure the canyon indicated for PV, are shown in pink.