Outcome	Assumption	Risk ratio	Lower 95% CI	Upper 95% CI	% change from available case analysis
Loss of 3+ lines visual acuity at 6 months	Missing at random (available case analysis)	0.755	0.556	1.025	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.742	0.555	0.994	2%
	Odds of outcome in not observed half odds of outcome in observed	0.77	0.559	1.061	‐2%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.815	0.596	1.114	‐8%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice  odds of outcome in observed in control group	0.7	0.516	0.949	7%
Loss of 3+ lines visual acuity at 12 months	Missing at random (available case analysis)	0.905	0.745	1.1	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.899	0.745	1.084	1%
	Odds of outcome in not observed half odds of outcome in observed	0.915	0.748	1.118	‐1%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.975	0.804	1.183	‐8%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice  odds of outcome in observed in control group	0.837	0.683	1.024	8%
Loss of 3+ lines visual acuity at 24 months	Missing at random (available case analysis)	0.81	0.636	1.033	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.817	0.649	1.028	‐1%
	Odds of outcome in not observed half odds of outcome in observed	0.807	0.627	1.038	0%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.856	0.683	1.074	‐6%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice  odds of outcome in observed in control group	0.768	0.593	0.994	5%
Loss of 6+ lines at 6 months	Missing at random (available case analysis)	0.423	0.191	0.934	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.406	0.186	0.888	4%
	Odds of outcome in not observed half odds of outcome in observed	0.44	0.199	0.973	‐4%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.488	0.225	1.055	‐15%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice  odds of outcome in observed in control group	0.365	0.163	0.82	14%
Loss of 6+ lines at 12 months	Missing at random (available case analysis)	0.62	0.443	0.868	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.61	0.441	0.845	2%
	Odds of outcome in not observed half odds of outcome in observed	0.633	0.45	0.891	‐2%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.683	0.481	0.97	‐10%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice  odds of outcome in observed in control group	0.561	0.401	0.785	10%
Loss of 6+ lines at 24 months	Missing at random (available case analysis)	0.811	0.638	1.032	0%
	Odds of outcome in not observed twice odds of outcome in observed	0.812	0.644	1.023	0%
	Odds of outcome in not observed half odds of outcome in observed	0.815	0.637	1.042	0%
	Odds of outcome in not observed twice odds of outcome in observed in treatment group and odds of outcome in not observed half odds of outcome in observed in control group	0.89	0.701	1.13	‐10%
	Odds of outcome in not observed half odds of outcome in observed in treatment group and odds of outcome in not observed twice odds of outcome in observed in control group	0.741	0.58	0.947	9%