Kacperek 2001.

Methods	Single centre. Allocation: unclear. Masking: participant ‐ no; provider ‐ no; outcome ‐ no. Exclusions after randomisation: not stated.
Participants	Country: UK. Number randomised: 66. Mean age: 76 years. Sex: Inclusion criteria: Aged 50+ with subfoveal CNV (classic) and evidence of AMD e.g. drusen, VA > 6/60. Exclusion criteria: diabetes, severe hypertension and retinal vascular disease, myopia.
Interventions	Treatment: 18 Gy (4 x 4.5 Gy). Control: observation. Duration:4 days.
Outcomes	Visual acuity.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	"Patients [...] were randomised to between treatment and control". Page 7, introduction.
Allocation concealment?	Unclear risk	Not reported.
Blinding? Visual acuity	High risk	No masking reported. No sham intervention in the control group.
Incomplete outcome data addressed? All outcomes	High risk	38 patients in the treatment arm, 28 for the control arm. 28/38 and 20/28 seen at 12 months. No information on people not seen.
Free of selective reporting?	High risk	See additional table 3.
Free of other bias?	Low risk