Kacperek 2001.
Methods | Single centre. Allocation: unclear. Masking: participant ‐ no; provider ‐ no; outcome ‐ no. Exclusions after randomisation: not stated. | |
Participants | Country: UK. Number randomised: 66. Mean age: 76 years. Sex: Inclusion criteria: Aged 50+ with subfoveal CNV (classic) and evidence of AMD e.g. drusen, VA > 6/60. Exclusion criteria: diabetes, severe hypertension and retinal vascular disease, myopia. | |
Interventions | Treatment: 18 Gy (4 x 4.5 Gy). Control: observation. Duration:4 days. | |
Outcomes | Visual acuity. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | "Patients [...] were randomised to between treatment and control". Page 7, introduction. |
Allocation concealment? | Unclear risk | Not reported. |
Blinding? Visual acuity | High risk | No masking reported. No sham intervention in the control group. |
Incomplete outcome data addressed? All outcomes | High risk | 38 patients in the treatment arm, 28 for the control arm. 28/38 and 20/28 seen at 12 months. No information on people not seen. |
Free of selective reporting? | High risk | See additional table 3. |
Free of other bias? | Low risk |