Comparison 3. Clinical improvement.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Reaching Fontaine stage II	2	124	Risk Difference (M‐H, Fixed, 95% CI)	0.33 [0.19, 0.47]
2 Reaching Fontaine stage III	2	206	Risk Difference (M‐H, Random, 95% CI)	0.07 [‐0.24, 0.38]
3 Ulcer healing and hypertension	2	72	Risk Difference (M‐H, Fixed, 95% CI)	‐0.54 [‐0.73, ‐0.35]
3.1 Hypertensives	1	44	Risk Difference (M‐H, Fixed, 95% CI)	‐0.57 [‐0.80, ‐0.33]
3.2 Non‐hypertensives	1	28	Risk Difference (M‐H, Fixed, 95% CI)	‐0.5 [‐0.82, ‐0.18]