Date	Event	Description
17 January 2013	New citation required but conclusions have not changed	Searches re‐run but no new studies identified. Review search dates updated, minor copy edits made to text. Conclusions not changed.
17 January 2013	New search has been performed	Searches re‐run but no new studies identified. Review search dates updated.
24 September 2008	New search has been performed	Searches re‐run and no new studies found. One additional report (Klomp 2006) added to ESES study. Correction made to the analysis results reported in the last paragraph of "Effects of Interventions", Limb salvage. Plain language summary added.
8 July 2008	Amended	Converted to new review format.
24 June 2005	New citation required but conclusions have not changed	No new trials found at last search. Review updated with minor formatting changes and correction to the numbers of amputations in the ESES trial, in accordance with the Comment submitted by Klomp and Steyerberg.
16 November 2004	Amended	Synopsis added.
4 November 2004	Feedback has been incorporated	Feedback and response to feedback added.