Table 1.
A summary of the demographics, treatment and outcome of individual cases presenting with late-onset ALF in WD from the previous literature, NHSBT data and current case.
| Age | Sex | Tx | Outcome | Cp (g/L) [>0.15] | s-Cu (μmol/L) [11-20] | ncb-Cu (μmol/L)[<2.4] | u-Cu (μmol/day) [>1.6] | Reference/Source |
|---|---|---|---|---|---|---|---|---|
| 64 | F | No | Died | 0.18 | 16.5 | 7.5∗ | 14.1 | Amano et al. 201815 |
| 58 | F | No | Died | 0.12 | 11.4 | 5.4∗ | – | Danks et al. 199016 |
| 54 | F | Yes | Survived | 0.18 | 14.0∗ | 5.1 | 35.7 | Gow et al. 200012 |
| 44 | F | No | Died | 0.14 | 28.0 | 21.1∗ | – | Danks et al. 199016 |
| 44 | F | No | Died | 0.14 | 27.4∗ | 20.5 | – | Gow et al. 200012 |
| 44 | F | Yes | Died | 0.25 | 58.3 | 45.9∗ | 139.3 | Kerber et al. 200314 |
| 42 | F | Yes | Survived | – | – | – | – | Bellary et al. 199313 |
| 55 | F | No | (Delisted) | – | – | – | – | NHSBT registry |
| 45 | F | Yes | Survived | – | – | – | – | NHSBT registry |
| 44 | M | Yes | Survived | – | – | – | – | NHSBT registry |
| 43 | M | Yes | Survived | – | – | – | – | NHSBT registry |
| 41 | F | Yes | Died | – | – | – | – | NHSBT registry |
| 41 | M | Yes | Survived | – | – | – | – | NHSBT registry |
| 40 | M | Yes | Survived | – | – | – | – | NHSBT registry |
| 40 | M | Yes | Survived | – | – | – | – | NHSBT registry |
| 62 | M | Yes | Survived | 0.13 | 16.7 | 10.3∗ | – | Current case |
Abnormal results are highlighted in bold with reference ranges in brackets.
ALF, acute liver failure; Cp, caeruloplasmin; s-Cu, serum copper; ncb-Cu, non-caeruloplasmin-bound copper; NHSBT, NHS blood and transplant; Tx, transplantation; u-Cu, urinary copper output; WD, Wilson's disease.
∗
Denotes biochemical parameters that are calculated from other values.