Table 1.
Wilcoxon Tests for the AKP Effects in the 27 MAD (Microbiome-Associated Diseases) Case Studies Based on the Beta-Diversity in Hill Numbers, Portion of Results Excerpted from Table S3
| Microbiome | Treatments (Healthy vs. Diseased) | Diversity Order | Average of Healthy (H) Treatments | Average of Diseased (D) Treatments | p Value (H≠D) | p value (H < D) AKP |
p value (H > D) Anti-AKP |
|---|---|---|---|---|---|---|---|
| IBD1 | Healthy vs. CD | q=0 | 1.678 | 1.696 | 0.036 | 0.018 | 0.982 |
| q=1 | 1.619 | 1.607 | 0.850 | 0.575 | 0.425 | ||
| q=2 | 1.667 | 1.602 | 0.033 | 0.983 | 0.017 | ||
| q=3 | 1.691 | 1.598 | 0.012 | 0.994 | 0.006 | ||
| Healthy vs. UC | q=0 | 1.678 | 1.812 | 0.000 | 0.000 | 1.000 | |
| q=1 | 1.619 | 1.792 | 0.000 | 0.000 | 1.000 | ||
| q=2 | 1.667 | 1.811 | 0.000 | 0.000 | 1.000 | ||
| q=3 | 1.691 | 1.823 | 0.000 | 0.000 | 1.000 | ||
| Obesity | Lean vs. Overweight | q=0 | 1.631 | 1.608 | 0.000 | 1.000 | 0.000 |
| q=1 | 1.605 | 1.591 | 0.091 | 0.955 | 0.045 | ||
| q=2 | 1.655 | 1.689 | 0.037 | 0.019 | 0.981 | ||
| q=3 | 1.678 | 1.736 | 0.008 | 0.004 | 0.996 | ||
| Lean vs. Obese | q=0 | 1.631 | 1.618 | 0.000 | 1.000 | 0.000 | |
| q=1 | 1.605 | 1.585 | 0.000 | 1.000 | 0.000 | ||
| q=2 | 1.655 | 1.675 | 0.001 | 0.000 | 1.000 | ||
| q=3 | 1.678 | 1.719 | 0.000 | 0.000 | 1.000 | ||
| CRC | Healthy vs. CRC | q=0 | 1.929 | 1.946 | 0.000 | 0.000 | 1.000 |
| q=1 | 1.954 | 1.971 | 0.000 | 0.000 | 1.000 | ||
| q=2 | 1.977 | 1.987 | 0.000 | 0.000 | 1.000 | ||
| q=3 | 1.980 | 1.989 | 0.000 | 0.000 | 1.000 | ||
| HIV1 | Negative vs. ART | q=0 | 1.635 | 1.675 | 0.000 | 0.000 | 1.000 |
| q=1 | 1.697 | 1.733 | 0.000 | 0.000 | 1.000 | ||
| q=2 | 1.759 | 1.787 | 0.005 | 0.002 | 0.998 | ||
| q=3 | 1.780 | 1.813 | 0.002 | 0.001 | 0.999 | ||
| Negative vs. Non-ART | q=0 | 1.635 | 1.730 | 0.000 | 0.000 | 1.000 | |
| q=1 | 1.697 | 1.783 | 0.000 | 0.000 | 1.000 | ||
| q=2 | 1.759 | 1.825 | 0.000 | 0.000 | 1.000 | ||
| q=3 | 1.780 | 1.847 | 0.000 | 0.000 | 1.000 | ||
| Type 1 Diabetes (T1D) and Obesity | Normal Healthy vs. Normal T1D |
q=0 | 1.535 | 1.541 | 0.007 | 0.003 | 0.997 |
| q=1 | 1.615 | 1.605 | 0.546 | 0.727 | 0.273 | ||
| q=2 | 1.724 | 1.669 | 0.014 | 0.993 | 0.007 | ||
| q=3 | 1.759 | 1.690 | 0.006 | 0.997 | 0.003 | ||
| Obesity Healthy vs. Obesity T1D | q=0 | 1.476 | 1.577 | 0.000 | 0.000 | 1.000 | |
| q=1 | 1.539 | 1.606 | 0.027 | 0.014 | 0.987 | ||
| q=2 | 1.599 | 1.642 | 0.010 | 0.005 | 0.995 | ||
| q=3 | 1.622 | 1.650 | 0.019 | 0.010 | 0.990 | ||
| Gout | Healthy vs. Gout | q=0 | 1.666 | 1.775 | 0.000 | 0.000 | 1.000 |
| q=1 | 1.533 | 1.682 | 0.000 | 0.000 | 1.000 | ||
| q=2 | 1.596 | 1.696 | 0.000 | 0.000 | 1.000 | ||
| q=3 | 1.636 | 1.710 | 0.000 | 0.000 | 1.000 | ||
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CD, Crohn's Disease; UC, Ulcerative Colitis; IBD, Inflammatory Bowel Disease; CRC, Colorectal Cancer; ART, Antiretroviral Therapy.