Skip to main content
. 2020 Mar 26;17(7):931–938. doi: 10.7150/ijms.43030

Table 2.

HPV16LCR variations in the case and control groups in A1-A3, A4 and D3 sub-lineages

Genome position A1-A3-Case (n=27) A1-A3-Control (n=40) P Value A4-Case (n=109) A4-Control (n=76) P Value D3-Case (n=3)
Variation Frequency (%) Variation Frequency (%) Variation Frequency (%) Variation Frequency (%) Variation Frequency (%)
A7167G 14 51.9 26 65.0 0.282a 0 0.0 0 0.0 - 0 0.0
A7173C 0 0.0 6 15.0 0.074c 0 0.0 0 0.0 - 0 0.0
C7174A 27 100.0 40 100.0 - 3 2.8 0 0.0 0.270c 3 100.0
T7175G 2 7.4 2 5.0 1.000c 0 0.0 0 0.0 - 0 0.0
C7176T 27 100.0 40 100.0 - 0 0.0 0 0.0 - 3 100.0
C7200T 27 100.0 40 100.0 - 0 0.0 0 0.0 - 3 100.0
A7232C 1 3.7 5 12.5 0.197c 0 0.0 3 3.9 0.068c 3 100.0
T7269C 27 100.0 40 100.0 - 0 0.0 0 0.0 - 3 100.0
C7286A 27 100.0 40 100.0 - 0 0.0 0 0.0 - 3 100.0
C7288A 27 100.0 40 100.0 - 40 36.7 21 27.6 0.197a 3 100.0
T7301G 2 7.4 0 0.0 0.159c 0 0.0 0 0.0 - 0 0.0
C7309T 2 7.4 5 12.5 0.693c 0 0.0 0 0.0 - 0 0.0
A7338T 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
T7379C 0 0.0 2 5.0 0.512c 0 0.0 0 0.0 - 0 0.0
C7393T 0 0.0 2 5.0 0.512c 0 0.0 0 0.0 - 3 100.0
C7394T 2 7.4 5 12.5 0.693c 0 0.0 0 0.0 - 3 100.0
A7418G 0 0.0 0 0.0 - 18 16.5 14 18.4 0.736a 0 0.0
G7428A 0 0.0 0 0.0 - 26 23.9 25 32.9 0.176a 0 0.0
G7435T 0 0.0 0 0.0 - 2 1.8 0 0.0 0.513c 0 0.0
A7451C 2 7.4 0 0.0 0.159c 0 0.0 0 0.0 - 0 0.0
A7484C 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
G7488A 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
C7613A 0 0.0 0 0.0 - 3 2.8 1 1.3 0.645c 0 0.0
A7659G 0 0.0 0 0.0 - 15 13.8 5 6.6 0.122a 0 0.0
C7668T 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
C7688A 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
T7699C 0 0.0 2 5.0 0.512c 0 0.0 0 0.0 - 0 0.0
G7701A 0 0.0 2 5.0 0.512c 0 0.0 0 0.0 - 0 0.0
T7713G 3 11.1 7 17.5 0.711b 0 0.0 0 0.0 - 0 0.0
A7728C 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
C7729A 19 70.4 31 77.5 0.511a 0 0.0 0 0.0 - 3 100.0
T7742G 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
C7763T 0 0.0 0 0.0 - 4 3.7 0 0.0 0.145c 3 100.0
C7780T 27 100.0 40 100.0 - 78 71.6 57 75.0 0.604a 3 100.0
C7785T 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
G7825A 0 0.0 0 0.0 - 9 8.3 4 5.3 0.433a 0 0.0
A7829C 0 0.0 0 0.0 - 12 11.0 7 9.2 0.692a 0 0.0
A7841G 27 100.0 40 100.0 - 0 0.0 0 0.0 - 3 100.0
G7867A 0 0.0 3 7.5 0.267c 0 0.0 1 1.3 0.411c 0 0.0
A7872G 0 0.0 0 0.0 - 10 9.2 11 14.5 0.264a 0 0.0
C7873G 0 0.0 0 0.0 - 9 8.3 14 18.4 0.039a 0 0.0
C7885G 0 0.0 0 0.0 - 0 0.0 0 0.0 - 3 100.0
C13T 0 0.0 0 0.0 - 6 5.5 2 2.6 0.474c 0 0.0
T24C 27 100.0 40 100.0 - 2 1.8 0 0.0 0.513c 3 100.0
A49C 0 0.0 2 5.0 0.512c 0 0.0 0 0.0 - 0 0.0

Note: The reference HPV16 LCR sequence used was AF534061.1. a Pearson Chi-Square; b Continuity Correction; c Fisher's Exact Test.