Table 3.
Univariate and multivariate analysis of factors predicting response to tolvaptan
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | ||
| Age (≥75 years) | 1.18 (0.48-2.93) | 0.72 | |||
| Sex (male) | 0.99 (0.39-2.57) | 0.99 | |||
| BMI (≥24) | 3.11 (1.12-8.63) | 0.03 | 5.14 (1.23-22.10) | 0.03 | |
| Child-Pugh (classification C) | 1.58 (0.63-3.95) | 0.33 | |||
| Complication of HCC | 0.59 (0.24-1.48) | 0.26 | |||
| Serum sodium (≥ 133 mEq/L) | 2.24 (0.74-6.77) | 0.15 | 4.40 (0.52-37.20) | 0.15 | |
| Serum creatinine (≥ 0.8 mg/dL) | 0.411 (0.15-1.12) | 0.08 | 1.35 (0.17-10.51) | 0.08 | |
| Serum urea nitrogen (≥ 21 mg/dL) | 0.493 (0.197-1.23) | 0.13 | 0.60 (0.08-4.25) | 0.61 | |
| Serum albumin (≥ 2.5 g/dL) | 0.258 (0.07-0.97) | 0.04 | 0.43 (0.02-8.45) | 0.68 | |
| Serum total bilirubin (≥ 1.6 mg/dL) | 1.83 (0.74-4.55) | 0.19 | 2.44 (0.34-17.00) | 0.48 | |
| Platelet (≥ 8×104/μL) | 1.20 (0.49-2.94) | 0.70 | |||
| Urinary specific gravity (≥ 1.018) | 5.75 (1.60-20.7) | <0.01 | 6.91 (1.30-36.6) | 0.04 | |