Table 4.
Univariate and multivariate analysis of factors predicting OS
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
| Age (≥70 years) | 0.72 (0.39-1.30) | 0.27 | ||
| Sex (male) | 1.21 (0.64-2.29) | 0.55 | ||
| Child-Pugh (classification C) | 2.25 (1.25-4.05) | <0.01 | 2.20 (1.03-4.70) | 0.04 |
| Complication of HCC | 2.12 (1.15-3.90) | 0.02 | 2.73 (1.35-5.52) | <0.01 |
| Serum sodium (≥133 mEq/L) | 0.29 (0.14-0.611) | <0.01 | 0.45 (0.20-1.00) | 0.05 |
| Serum creatinine (≥0.8 mg/dL) | 1.09 (0.59-2.03) | 0.79 | ||
| Serum urea nitrogen (≥ 21 mg/dL) | 0.80 (0.44-1.46) | 0.47 | ||
| Serum albumin (≥2.5 g/dL) | 0.52 (0.26-1.03) | 0.06 | 0.58 (0.26-1.30) | 0.19 |
| Serum total bilirubin (≥1.6 mg/dL) | 2.69 (1.44-5.01) | <0.01 | 1.35 (0.62-2.93) | 0.45 |
| Platelets (≥8x104/uL) | 1.14 (0.63-2.07) | 0.66 | ||
| Response to tolvaptan | 1.02 (0.53-2.00) | 0.95 | ||