Table 5.
Univariate and multivariate analysis of factors predicting OS in tolvaptan responders (n=55)
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | ||
| Age (≥70 years) | 0.67 (0.33-1.35) | 0.26 | |||
| Sex (male) | 1.26 (0.61-2.61) | 0.54 | |||
| Child-Pugh (classification C) | 2.05 (1.01-4.18) | 0.05 | 1.17 (0.29-4.71) | 0.83 | |
| Complication of HCC | 1.70 (0.84-3.45) | 0.14 | 6.63 (1.43-30.78) | 0.02 | |
| Serum sodium (≥133 mEq/L) | 0.39 (0.12-1.04) | 0.06 | 0.00 (0.00-Inf) | 1.00 | |
| Serum creatinine (≥0.8 mg/dL) | 1.04 (0.52-2.10) | 0.90 | |||
| Serum albumin (≥2.5 g/dL) | 0.42 (0.19-0.91) | 0.03 | 0.18 (0.03-1.09) | 0.06 | |
| Serum total bilirubin (≥1.6 mg/dL) | 2.59 (1.22-5.50) | 0.01 | 2.36 (0.38-14.78) | 0.36 | |
| Platelets (≥8x104/uL) | 1.39 (0.65-2.97) | 0.39 | |||
| Early re-exacerbation | 2.83 (1.15-6.99) | 0.02 | 6.28 (1.87-21.07) | <0.01 | |
| Reduction of conventional diuretics | 0.50 (0.24-1.06) | 0.07 | 0.63 (0.25-1.58) | 0.32 | |