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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Immunity. 2019 Sep 3;51(4):750–765.e10. doi: 10.1016/j.immuni.2019.08.009

Figure 4. Differential gene expression can be detected during asymptomatic P. falciparum infection in Immune but not Delayed Fever children.

Figure 4.

Paired analysis of infected (I) vs. uninfected (U) samples is indicated by Δ. (A) Principal components analysis of paired RNA-seq samples (infected – uninfected baseline for each subject) with 95% confidence intervals (ellipses). (B) Unsupervised hierarchical clustering heat map for the top 50% most variably expressed genes (7,072 genes) using the complete method and Pearson correlation distance. (C) Differential gene expression for paired infected vs. uninfected baseline samples within each clinical class. For smear density plots, DEGs with FDR<5% are shown as red points. Venn diagram shows the number of differentially expressed genes (DEGs) at a false discovery rate (FDR) <5% with no fold-change cut-off. ns = not significant. Please see also Supplemental Datasets 3 and 4 as well as Figure S6.