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Ultrasmall GNs in cancer gene therapy. Schematic representation of the distribution and localization behavior of smaller (2 nm) and larger (10 nm) GNs in MCF-7 cancer cells. The ultrasmall 2 nm GNs were able to enter the nucleus, and were used as a carrier to deliver a triplex-forming oligonucleotide (TFO) to regulate gene expression. Adapted with permission from 88, copyright 2014 American Chemical Society.
