Figure 1.

The distribution of Schwann cells in PDAC and normal pancreas (NP) tissues. A. Representative double immunolabeling fluorescent images showing that SCs are relatively scarce in NP (upper panel), but are widely distributed in the PDAC TME. In PDAC tissues, SCs were detected as present not only within nerves (middle panel), but also outside nerves (lower panel, white arrows). Scale bar: 50 μm. B. Compared with NP, PDAC tissues exhibited an elevated SC density. A paired Students' t test or an unpaired Students' t test were applied for the statistical analyses. C. Kaplan-Meier survival analysis based on the intra-tumoral SC density of 80 patients with PDAC (log-rank test). *p < 0.05, **p < 0.01, ***p < 0.001.