Table 2.
Univariate and multivariate analysis of different prognostic parameters in patients with PDAC
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age | 0.689 | 0.386-1.231 | 0.208 | ||||
| Gender | 1.083 | 0.576-2.036 | 0.804 | ||||
| Histological grade (Well vs. Moderate or Poor) | 0.786 | 0.469-1.317 | 0.36 | ||||
| Lymph node metastasis | 1.762 | 0.951--3.266 | 0.072 | ||||
| Distant metastases | 3.447 | 1.745-6.808 | < 0.001*** | 1.004 | 0.312-3.234 | 0.994 | |
| TNM stage (Ⅲ-Ⅳ vs. Ⅰ-Ⅱ) | 3.181 | 1.711-5.915 | < 0.001*** | 3.373 | 1.185-9.601 | 0.023* | |
| Vascular invasion | 1.138 | 0.613-2.113 | 0.681 | ||||
| Perineural invasion | 0.723 | 0.405-1.291 | 0.273 | ||||
| Intra-tumor GFAP+S100+ (High vs. low) | 1.867 | 1.032-3.38 | 0.039* | 2.015 | 1.038-3.911 | 0.038* | |
Abbreviations: HR = hazard ratio; 95% CI = 95% confidence interval; *p < 0.05, ** p< 0.01, ***p < 0.001.