Table 1.

MHV mimic peptides fail to induce EAE

Immunizing Aga)	No. EAE	Mean group score ± SEM	Mean day of onset ± SEM
OVA323–339	0/5	0.0 ± 0.0	0.0 ± 0.0
PLP139–151	5/5	4.0 ± 0.0	12.2 ± 0.8
PLP130–159	5/5	3.6 ± 0.5	13.4 ± 1.5
MHV3821–3832	0/5	0.0 ± 0.0	0.0 ± 0.0
MHV3813–3842	0/5	0.0 ± 0.0	0.0 ± 0.0

^a) Separate groups of mice were immunized s.c. on day 0 with 100 µg of either “self” myelin peptide PLP (PLP_139–151), PLP 30‐mer (PLP_130–159), MHV mimic peptide (MHV_3821–3832), MHV 30‐mer (MHV_3813–3842) or a control non‐self, non‐mimic peptide OVA_323–339 and observed for signs of clinical EAE. Results represent the number of mice that developed EAE, the mean group clinical score ± SEM, and the mean day of onset ± SEM.