Figure 5.

Pristane‐induced arthritis is dependent on IFN‐γ for T‐cell priming. (A‐B) Antibodies to INF‐γ (DB‐1) (A) and IL‐17 (17F3) (B) were administrated s.c. on day 2, 4, and 6 after pristane administration (control rats were injected with PBS; since, DB‐1 and 17F3 are both of mouse IgG1 isotype). (C) Day of disease onset for rats treated with DB‐1 (left panel) and 17F3 (right panel). n = 7–8 rats/group as indicated in figure; *p < 0.05; **p < 0.01; ***p < 0.001 (Mann–Whitney). Data are shown as mean + SEM and are pooled from two independent experiments with similar results.