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. 2009 May 6;39(7):618–625. doi: 10.1111/j.1365-2362.2009.02153.x

Figure 1.

Figure 1

 Pulmonary SARS‐CoV infection leads to myocardial SARS‐CoV infection and down‐regulation of myocardial ACE2 expression. (a–d) Human SARS‐CoV mRNA in the hearts of infected mice showing a clear dependence on ACE2 for myocardial SARS‐CoV infection (a) with down‐regulation of myocardial Ace2 mRNA expression based on real‐time PCR (b) and myocardial ACE2 protein levels shown by Western blot analysis (c) and quantification (d) in response to pulmonary SARS‐CoV infection. *P < 0·01 compared with infected Ace2+/y group; #P < 0·01 compared with uninfected group, n = 5, ND, not detectable. (e–g) Discordant changes in myocardial Ace2 mRNA and myocardial ACE2 protein levels in encephalomyocarditis (EMC) virus‐induced myocarditis with real‐time PCR showing reduced myocardial Ace2 mRNA (e) with increased myocardial ACE2 protein levels based on Western blot analysis (f) and quantification (g). **P < 0·01 compared with placebo group, n = 5.