Figure 3.
Increased macrophage infiltration in the absence of increased lymphocytic infiltration in the left ventricle of patients who died from SARS. (a–e) Representative anti‐CD68‐stained immunohistochemistry section from a patient who died from non‐SARS related sepsis (bacterial pneumonia) (a), SARS with evidence of SARS‐CoV in the heart (b), SARS without evidence of SARS‐CoV in the heart (c) and a positive control section obtained from human spleen (d) with quantification of myocardial macrophage count (e). (f–i) Representative anti‐CD3 immunohistochemistry illustrating a representative section from a patient who died from SARS with evidence of SARS‐CoV in the heart (f), SARS without evidence of SARS‐CoV in the heart (g) and a positive control section obtained from human spleen (h) with quantification of myocardial lymphocyte count (i). Scale bar represents 50 μM. #P < 0·05 compared with all other groups. VL‐ve and VH‐ve = patients who died from a non‐SARS related sepsis (open bar), VL+ve and VH+ve = patients who died from SARS with SARS‐CoV in the heart (grey bar) and VL+ve and VH‐ve = patients who died from SARS without SARS‐CoV in the heart (closed bar), n = 7 per group.