A, Plots by breast cancer subtype show overlapping ranges of tracer uptake. B, Representative fused positron emission tomography–computed tomography (PET-CT) of patient 28 (top) and patient 19 (bottom) illustrate degree of [18F]FluorThanatrace tumor uptake. ER+ indicates estrogen receptor–positive; HER2+, human epidermal growth factor receptor 2–positive; LOHneg, loss of heterozygosity negative; LOHpos, loss of heterozygosity positive; TNBC, triple negative breast cancer.
aBRCA2.
bBRCA1.
cCHEK2.