Table 2.
Items | HC (n = 23) | WMH | F/χ 2 | P | Post hoc analyses | |||
---|---|---|---|---|---|---|---|---|
NC (n = 19) | MCI (n = 22) | HC VS WMH‐NC | HC VS WMH‐MCI | WMH‐NC VS WMH‐MCI | ||||
Demographics | ||||||||
Age (y) | 62.3 ± 1.50 | 67.1 ± 1.66 | 65.1 ± 1.54 | 2.311 | .108b | – | – | – |
Education (y) | 12.7 ± 0.67 | 11.7 ± 0.73 | 11.00 ± 0.68 | 1.599 | .210b | – | – | – |
Gender (male/female) | 12/11 | 9/10 | 9/13 | 0.576 | .750a | – | – | – |
General cognition | ||||||||
MMSE | 29.2 ± 0.31 | 28.6 ± 0.34 | 27.3 ± 0.32 | 9.653 | <.001b, * | 0.206 | <0.001* | 0.006* |
MoCA‐BJ | 26.7 ± 0.36 | 26.4 ± 0.40 | 21.5 ± 0.37 | 61.959 | <.001b, * | 0.667 | <0.001* | <0.001* |
Composition Z scores of each cognitive domain | ||||||||
Episodic Memory | 0.45 ± 0.14 | 0.05 ± 0.16 | −0.51 ± 0.15 | 11.137 | <.001b, * | 0.065* | <0.001* | 0.011* |
AVLT‐DR | 0.35 ± 0.19 | 0.32 ± 0.21 | −0.64 ± 0.19 | 8.626 | .001b, * | 0.896 | <0.001* | 0.001* |
VR‐DR (WMS) | 0.54 ± 0.19 | −0.22 ± 0.21 | −0.37 ± 0.20 | 6.192 | .004b, * | 0.011* | 0.002* | 0.593 |
Information Processing Speed | 0.27 ± 0.17 | 0.18 ± 0.19 | −0.44 ± 0.18 | 4.816 | .011b, * | 0.720 | 0.005* | 0.020* |
TMT‐A (inverse) | 0.45 ± 0.20 | −0.02 ± 0.22 | −0.45 ± 0.2 | 5.138 | .009b, * | 0.120 | 0.002* | 0.142 |
Stroop A (inverse) | 0.20 ± 0.20 | 0.24 ± 0.22 | −0.41 ± 0.21 | 3.026 | .056b | – | – | – |
Stroop B (inverse) | 0.17 ± 0.20 | 0.31 ± 0.22 | −0.45 ± 0.21 | 3.729 | .030b, * | 0.640 | 0.035* | 0.015* |
Language | 0.25 ± 0.13 | −0.08 ± 0.19 | −0.19 ± 0.18 | 1.678 | .195 | – | – | – |
CVF | 0.01 ± 0.21 | 0.11 ± 0.23 | −0.11 ± 0.22 | 0.229 | .796 | – | – | – |
BNT | 0.48 ± 0.20 | −0.26 ± 0.22 | −0.28 ± 0.20 | 4.661 | .013b, * | 0.014* | 0.009* | 0.961 |
Executive Function | 0.20 ± 0.14 | 0.12 ± 0.16 | −0.32 ± 0.14 | 3.741 | .029b, * | 0.581 | <0.001* | <0.001* |
DST‐backward | 0.11 ± 0.21 | 0.02 ± 0.23 | −0.13 ± 0.22 | 0.320 | .727 | – | – | – |
TMT‐B (inverse) | 0.52 ± 0.19 | −0.01 ± 0.21 | −0.54 ± 0.19 | 7.490 | .001b, * | 0.239 | <0.001* | <0.001* |
Stroop C (inverse) | −0.02 ± 0.21 | 0.35 ± 0.26 | −0.28 ± 0.21 | 2.152 | .125 | – | – | – |
Values are presented as the mean ± standard error (SE).
Abbreviations: AVLT‐DR, Auditory Verbal Learning Test‐delayed recall; BNT, Boston Naming Test; CVF, category verbal fluency; DST, Digit Span Test; HC, health control; MCI, mild cognitive impairment; MMSE, mini mental state examination; MoCA‐BJ, Beijing version of the Montreal Cognitive Assessment; NC, normal cognition; Stroop A, B and C, Stroop Color and Word Tests A, B, and C; TMT‐A and TMT‐B, Trail Making Test‐A and B; VR‐DR, visual reproduction‐delay recall; WMH, white matter hyperintensities; WMS, Wechsler Memory Scale.
The p value was obtained by χ 2 test.
The p value was obtained by one‐way ANOVA.
Indicates a statistical difference between groups, P < .05.