Table 2.

Functions of CXCL5 in TME and/or metastatic niche

Functions of CXCL5	References
Promote tumor angiogenesis and lymphangiogenesis in TME	[51, 52]
Regulate the function of neutrophil in TME	[45]
Positively related to the risk of metastasis	[62, 63, 72]
Recruit immune cells
‐ Recruit neutrophils in TME and metastatic niche	[30, 42, 43, 44, 45]
‐ Recruit granulocytes to promote the formation of early metastatic microenvironment	[40, 49]
‐ Promote MDSCs infiltration in TME	[47, 48]
‐ Positively related to the extent of macrophage infiltration in TME	[50]
Promote cell proliferation of primary tumors	[26, 54, 55, 56, 57]

Abbreviations: CXCL5, CXC motif ligand 5; TME, tumor microenvironment; MDSC, myeloid‐derived suppressor cell.