TABLE 3.

Association between Aβ‐deposition (binary: positive/negative status, and continuous: SUVR classification) and cortical thickness in Insight 46

ROIs	Aβ‐negative mean cortical thickness (SD), mm	Aβ‐positive mean cortical thickness (SD), mm	Mean difference (95% CI), mm	P‐value	β‐Coefficient between SUVR and cortical thickness	P‐value
Frontal	2.76 (0.09)	2.75 (0.09)	−0.01 (−0.03, 0.01)	0.32	−0.10 (−0.24, 0.05)	0.18
Temporal	2.86 (0.09)	2.87 (0.09)	0.00 (−0.02, 0.03)	0.71	−0.03 (−0.15, 0.09)	0.64
Parietal	2.47 (0.08)	2.48 (0.09)	0.01 (−0.01, 0.03)	0.32	−0.02 (−0.15, 0.11)	0.82
Occipital	2.19 (0.09)	2.20 (0.1)	0.01 (−0.02, 0.03)	0.65	−0.07 (−0.22, 0.08)	0.37
ADsig Mayo	2.89 (0.09)	2.89 (0.09)	0.01 (−0.02, 0.03)	0.59	−0.05 (−0.18, 0.08)	0.48
ADsig Harvard	2.68 (0.07)	2.69 (0.08)	0.00 (−0.02, 0.02)	0.83	−0.05 (−0.17, 0.08)	0.44

Mean difference calculated following linear regression analysis with robust standard error. β‐Coefficients were adjusted for age at scan, sex, and WMHV.

Aβ, amyloid β; ADsig Mayo, surface area–weighted mean cortical thickness in entorhinal cortex, fusiform, inferior and middle temporal regions; ADsig Harvard, surface area–weighted mean cortical thickness in entorhinal cortex, parahippocampus, inferior parietal lobe, pars opercularis, pars orbitalis, pars triangularis, inferior temporal, temporal pole, precuneus, supramarginal gyrus, superior parietal, and superior frontal regions; ROIs, regions of interest; SUVR, standard uptake value ratio; WMHV, white matter hyperintensity volume.