TABLE 4.

Association between WMHV and cortical thickness in Insight 46

ROIs	β‐Coefficient between WMHV and cortical thickness†	P‐value	Interaction term between Aβ status and WMHV†	P‐value
Frontal	−3.55 (−5.07, −2.03)	<0.001*	3.65 (0.66, 6.65)	0.017*
Temporal	−3.3 (−4.81, −1.79)	<0.001*	5.77 (2.8, 8.72)	<0.001*
Parietal	−1.24 (−2.41, −0.06)	0.039*	−0.29 (−3.56, 2.97)	0.86
Occipital	−1.89 (−3.39, −0.39	0.013*	1.91 (−2.63, 6.47)	0.41
ADsig Mayo	−1.99 (−3.5, −0.47)	0.01*	6.07 (3.11, 9.04)	<0.001*
ADsig Harvard	−1.51 (−2.59, −0.44)	0.006*	1.17 (−1.56, 3.89)	0.4

β‐Coefficients were adjusted for age at scan, sex, and Aβ status.

Aβ, amyloid β; ADsig Mayo, surface area–weighted mean cortical thickness in entorhinal cortex, fusiform, inferior, and middle temporal regions; ADsig Harvard, surface area–weighted mean cortical thickness in entorhinal cortex, parahippocampus, inferior parietal lobe, pars opercularis, pars orbitalis, pars triangularis, inferior temporal, temporal pole, precuneus, supramarginal gyrus, superior parietal, and superior frontal regions; ROIs, regions of interest; SUVR, standard uptake value ratio; WMHV, white matter hyperintensity volume.

^*= P < 0.05.

^†= mm/ml × 10⁻³.