TABLE 5.

Association between WMHV and cortical thickness in Insight 46 following stratification based on Aβ status

ROIs	β‐Coefficient between WMHV and cortical thickness Aβ‐negative, n = 334†	P‐value	β‐Coefficient between WMHV and cortical thickness Aβ‐positive, n = 74†	P‐value
Frontal	−4.21 (−5.89, −2.53)	<0.001*	−0.56 (−3.2, 2.07)	0.67
Temporal	−4.35 (−5.9, −2.8)	<0.001*	1.3 (−1.2, 0.39)	0.29
ADsig Mayo	−3.13 (−4.66, −1.6)	<0.001*	2.9 (0.33, 5.47)	0.027*

β‐Coefficients were adjusted for age at scan and sex.

Aβ, amyloid β; ADsig Mayo, surface area–weighted mean cortical thickness in entorhinal cortex, fusiform, inferior, and middle temporal regions; ADsig Harvard, surface area–weighted mean cortical thickness in entorhinal cortex, parahippocampus, inferior parietal lobe, pars opercularis, pars orbitalis, pars triangularis, inferior temporal, temporal pole, precuneus, supramarginal gyrus, superior parietal, and superior frontal regions; ROIs, regions of interest; SUVR, standard uptake value ratio; WMHV, white matter hyperintensity volume.

^*= P < 0.05.

^† = mm/mL × 10⁻³.