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Rate of angiotensin II cleavage by ACE2 variants relative to the wild‐type. The initial rate of activity was determined in 100 mm NaCl, 50 mm HEPES buffer, pH 7.4, by HPLC. Values are the mean ± standard error of three independent determinations.
| ACE2 variant | v (nmol·min−1·mg−1) | Relative activity (%) |
|---|---|---|
| Wild‐type | 20.30 ± 0.40 | 100.0 |
| R169Q | 0.22 ± 0.01 | 1.1 |
| W271A | 0.19 ± 0.01 | 0.9 |
| K481Q | 14.58 ± 0.77 | 71.8 |
| R514Q | 36.41 ± 1.49 | 179.3 |
| R169QK481QR514Q | 40.19 ± 1.45 | 204.4 |
