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The two distinct catalytic sites of LTA4H. The cocrystal structure of LTA4H in complex with substrate analog OPB‐Pro (purple) and ARM1 (green), a selective inhibitor of the epoxide hydrolase activity 56. Ligands are shown as colored sticks, with dots indicating atomic radii. LTA4H is shown in gray with catalytic zinc (sphere), residues of the zinc‐binding motif (sticks), and solvent‐exposed area (surface representation) indicated.
