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Bestatin binds APN in a noncanonical pose (orange) 7, rather than the conserved canonical pose for other M1 aminopeptidases (blue, APA in complex with bestatin used as representative 9). APN solvent accessible surface area shown in gray and residues of the zinc‐binding motif as gray sticks. Catalytic zinc ions shown as spheres for APN (orange) and APA (blue).
