Table 2.
Compilation of several diseases reported to be possibly associated with mechanism of molecular mimicry
Disease | Cross‐reactive immune responses | References |
---|---|---|
Primary biliary cirrhosis | Pyruvate dehydrogenase complex Anti‐mitochondrial response HLA DRa Microorganisms: E. coli, S. cerevisial | 63–66 |
Rasmussen's encephalitis | Antiglutamate receptor (GLUR3) response Microorganisms | 66, 67 |
Multiple sclerosis | Myelin proteins Viruses: corona, measles, mumps, EBV, herpes, etc. | 18, 19, 47, 68–71 |
Myasthenia gravis | Acetylcholine receptor Neurofilaments Herpes | 39, 72, 73 |
Guillain‐Barre | Peripheral nerve Gangliosides Campylobacter jejuni | 74–76 |
Insulin‐dependent diabetes | Islet antigens (GAD 65, proinsulin carboxypeptidase H) Coxsackie B Rotaviruses Hepatitis C, herpes, rhino‐, hanta‐, and faviviruses Retroviral | 40, 77–80 |
Myocardial (heart) | ADP/ATP carrier protein Cardiac myosin Myocardial cell surface protein Coxsackie B3, streptococci | 35–37, 81, 82 |
Celiac | Gliadin Enterocyte surface molecules Adenoviruses Enteric microbes | 83, 84 |
Graft vs. host transplantation | Aminopeptidase N HLA molecule Cytomegalovirus | 85, 86 |
Pemphigus | Desmosomes VH‐CDR3 | 87 |
Herpes stomal keratitis | Herpes simplex Corneal antigen(s) | 88 |
Autoimmune uveitis | S‐antigen IRBP Viruses | 38, 89 |
Peptic ulcer/gastric CA | H. pylori Self antigens on gastric mucosa | 90 |
Pathogenesis in: | ||
HIV | 91–94 | |
Lyme disease | 95 | |
Streptococcal | 82, 96 | |
Syphilis | 97 | |
Prion protein disease | 98 | |
Trypanosoma | 99–102 |